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Can gluten intolerance cause depression?


Gluten intolerance has been a hotly debated topic in recent years, with more and more people claiming that they are sensitive to gluten.

This condition, also known as “gluten sensitivity,” is a disorder that affects the digestive system.

Gluten is a protein found in wheat, barley, and rye. People who are gluten intolerant have a negative reaction to this protein.

This reaction can cause a range of symptoms, including bloating, gas, diarrhea, constipation, headaches, fatigue, joint pain, and skin rashes.

But can gluten intolerance also cause depression?

Depression and gluten intolerance

It is possible that intolerance to gluten can increase the likelihood of experiencing symptoms associated with depression in select individuals. But the research on this topic is not entirely clear. Additional research is necessary to establish a concrete correlation between gluten and depression.

A previous 2009 longitudinal study found that individuals with celiac disease had a higher probability of experiencing depression. However, the study did not find that a gluten-free diet improved their symptoms, leading the authors to suggest that the reduced quality of life associated with celiac disease may be related to depression instead of gluten itself.

In 2014, a small study revealed that reintroducing gluten to individuals previously on a gluten-free diet with controlled gluten sensitivity led to an immediate increase in symptoms related to depression. Nonetheless, their gastrointestinal symptoms were not aggravated, highlighting the possibility that gluten may have a direct impact on mood-related symptoms.

In a 2020 literature review spanning two decades of research, the authors concluded that the immune response triggered by gluten intolerance could lead to neurological and psychiatric responses. Although ongoing research regarding this matter is inconclusive, some evidence indicates that gluten may influence symptoms of depression in individuals with gluten intolerance or sensitivity.

The Gut-Brain Connection

So, why might gluten intolerance cause depression?

The answer appears to lie in the gut-brain connection. The gut and the brain are connected through a complex network of nerves, chemicals, and hormones, known as the gut-brain axis. When the gut is inflamed, as is the case in people with gluten intolerance, this can lead to changes in the gut microbiome. This can, in turn, affect the immune system and the brain.

Studies have shown that the gut microbiome, which is made up of trillions of bacteria, can trigger inflammation elsewhere in the body, including the brain, which may influence brain function and mental health. This could lead to symptoms of depression, as well as anxiety and other mood disorders.

Other ways gluten intolerance might cause depression

While there is evidence to suggest that gluten intolerance can cause depression, it is also important to consider other factors. For example, people who suffer from digestive problems and other physical symptoms of gluten intolerance may be more likely to feel depressed simply because they feel unwell.

Similarly, people with gluten intolerance may be more likely to experience social isolation, as they may feel restricted by their diet.

In addition, people with gluten intolerance may also be more likely to be deficient in certain nutrients. These could include nutrients such as iron, vitamin B12, and folic acid, which can contribute to depression. In one study, researchers found that people with celiac disease were more likely to be deficient in vitamin B12 and folic acid than the general population. These two nutrients are essential for healthy brain function and can contribute to mood disorders when deficient.


The link between gluten intolerance and depression is complex and multifaceted. There is evidence to suggest that gluten intolerance can cause depression. However, this link may be indirect, through the gut-brain axis and the microbiome. Other factors may also play a role in the development of depression in people with gluten intolerance. These could include nutritional deficiencies and isolation.

If you suspect that you may be gluten intolerant, it is important to seek medical advice. Your doctor can conduct tests to determine whether you have a gluten intolerance or celiac disease. They can also provide guidance on how to manage your symptoms and improve your mental health.

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Annie Ingalls
Annie Ingalls

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